Many report have shown that rigorous thermic restriction , or strict diet , can increase longevity dramatically in lifeforms from barm to humans . But a field of study loose today shows one way to mime the life - extending effect of food deprivation – using drugs .
A team of researcher in the UK explored the purpose of a protein live as S6K1 , which turns out to play an over-the-top role in ripening and age - related disease . When the investigator grew mice lack the factor to produce S6K1 , their shiner lived importantly longer ( see chart – the crimson communication channel are mice without S6K1 ) . They also developed fewer age - related enfeeble condition .
distaff mouse without S6K1 lived slightly longer than their male person counterparts , and over 160 days longer than the restraint group . That think the distaff mouse lifespan increased by twenty percent .
mouse without S6K1 also lost weightiness , even if they ate more than average mice . In other words , a substance that could deflect the formulation of S6K1 would play a trick on the body into thinking that you ’d gone on a very rigorous diet . And it would make you sizable into an senior old age . The best part ?
In their paper , the researchers conclude :
It might be possible to educate drug discourse that pull wires S6K1 and AMPK to achieve ameliorate overall health in late life . Indeed , short - term rapamycin handling cut down fattiness in mouse , and Glucophage treatment [ often used against character 2 diabetes ] extends lifespan in shortly - go mice .
This is good news , because often when investigator make discoveries relate to longevity there is no contiguous pathway to manufacturing a life - extending drug . For all of us who want to stay healthy in old age while still consume sugar and fat once in a while , countenance ’s hope this enquiry team starts testing a drug based on their S6K1 find – and soon .
viaScience
BiologyDrugsScience
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